Migraine Patients Need Full Attention To Manage Their Lifestyle

Comparison of the effects of amitriptyline and flunarizine on weight gain and serum leptin, C peptide and insulin levels when used as migraine preventive treatment

This definitely goes into the “we’re mismanaging migraines” file folder. Since we are truly beginning to view migraines as a local manifestation of a systemic problem, drug therapy that worsens overall health is definitely a step in the wrong direction. Migraine patients need to be addressed with full attention to lifestyle to manage their headaches as well as lowering their risk of certain chronic diseases that migraine patients are at risk for.

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Migraine Med Helps Oxidative Stress

Flunarizine effects on oxidative stress in migraine patients

This is interesting and ties in with an article several weeks back in the Updates. In this study, flunarizine, used for migraines, lowers the levels of oxidative damage (as measured by TBARS, a functional marker for lipid peroxidation from oxidative stress) in migraine patients. Couple this with the finding several weeks ago that patients with a heart defect (patent foramen ovale) that was surgically repaired had 50% less migraines. I am starting to see a pattern developing for migraines where oxidative stress or lack of protective factors leads to the disruptions in cellular machinary via the mitachondria, subsequent damage to the lipid membrane and then increased neuronal excitability leading to seizures (of which migraine is a part of).

Flunarizine effects on oxidative stress in migraine patients – Cephalalgia, Vol 24, Issue 7, pp. 528-532 (Abstract) –

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