For those of you not familiar with the jargon, a refractory seizure is one that does not respond to medication.
Unfortunately, this is not a tiny fraction of epileptics. Rather, upwards of 1/3 of epileptics have seizures that do not respond to any medication that is used. The options that mainstream medicine have at this point are not pleasant. Vagal nerve stimulators embedded in your neck. Surgery to remove a part of your brain. Or, just deal with it.