Mitochondrial Dysfunction Leads To Neurodegenerative Disorders

Efficacy of coenzyme Q10 in migraine prophylaxis

Almost a 50% response with taking 300 mg CoQ10 per day.  Not too shabby.  This is yet another notch in the “mitochondrial dysfunction leads to neurodegenerative disorders” belt. 

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Causes Of Migraines To A Mitochondrial Dysfunction

CoQ10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine

Given that we have shifted our thinking of the cause of migraines to a mitochondrial dysfunction / oxidative stress model, the results of this study should come as no surprise. I still find it very bothersome, though, that we have so many patients being treated for migraines under a “pain control only” model without any thought to fixing the underlying mechanism.

The problem here is that oxidative stress leads to so many other chronic diseases that the patient and doctor just missed an opportunity to change the health trajectory away from one of chronic disease.

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Migraines Are Strongly Related To Oxidative Stress

Platelet membrane fluidity and peroxynitrite levels in migraine patients during headache-free periods

Two things to mention here.  First, we are seeing a sustained movement towards the concept that migraines, just like the seizures that clinicians are not yet willing to throw in the same category, is strongly related to oxidative stress and mitochondrial dysfunction.

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Mitochondrial Dysfunction And Migraine

Ok–so some still consider it a hypothesis. But once I get my book together (titled: Mitchondrial Dysfunction as the Root of All That is Evil in Chronic Diseases) everyone will consider it fact. This model fits very well into migraine but leaves a big gaping problem. Mitochondrial dysfunction can create a very large variety of problems (see title for future book, above…) and I have yet to have a migraine patient come into my office that has been treated w/ anything other than meds. If this model turns out to be correct, then we are grossly mismanaging our migraine patients by not addressing the problem. Rather, we are medicating to get rid of the symptoms.

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